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References OMIM Gene GeneReviews HGMD HGNC
last update : 04-01-2012
Symbol MEN4
Location 12p13.1
Name multiple endocrine neoplasia, type IV
Corresponding gene CDKN1B
Main clinical features
  • characterized by varying combinations of tumors of parathyroids, pancreatic islets, duodenal endocrine cells, and the anterior pituitary
  • less commonly associated tumors include foregut carcinoids, lipomas, angiofibromas, thyroid adenomas, adrenocortical adenomas, angiomyolipomas, and spinal cord ependymomas
  • Genetic determination autosomal dominant
    Function/system disorder endocrinology
    Type malignancy