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GENATLAS PHENOTYPE

last update : 17-01-2015

Symbol	MALTLY
Location	18q21.32
Name	mucosa-associated lymphoid tissue (MALT) lymphoma
Corresponding gene	MALT1
Other symbol(s)	MALT
Main clinical features	B-cell non-Hodgkin's lymphoma
Genetic determination	other
Function/system disorder
Type	malignancy

Mechanism(s)

Gene mutation	Chromosome rearrangement	Effect	Comments
	translocation		t(11;18)(q21;q21), t(1;14)(p22;q32) and t(14;18)(q32;q21) mutually exclusive affecting the MALT1 (18q21) and BCL10 (1p22) genes

Remark(s)

associated with aberrant subcellular localisation of the BCL10 protein found by immunochemistry