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GENATLAS PHENOTYPE

last update : 12/12/07

Symbol	MALTL
Location	1p22.3
Name	mucosa-associated lymphoid tissue (MALT) lymphomas
Other name(s)	B cell/lymphoma of mucosa, 10
Corresponding gene	BCL10
Main clinical features	lymphoma
Genetic determination	other
Function/system disorder	hematology
Type	malignancy

Gene product

Name	BCL10 protein

Mechanism(s)

Gene mutation	Chromosome rearrangement	Effect	Comments
	translocation		t(11;18)(q21;q21), t(1;14)(p22;q32) and t(14;18)(q32;q21) mutually excusive translocations affecting the MALT1 (18q21) and BCL10 (1p22.3) genes

Remark(s)

BCL10 immunohistochemistry is a simple technique to identify those MALT lymphoma cases with an underlying genetic aberration.