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last update : 14-05-2019
Symbol LQT16
Location 19q13.32
Name long QT syndrome 16
Corresponding gene CALM3
Main clinical features
  • fetal bradycardia with a very long QT interval; early-onset LQTS, calmodulinopathy
  • in the majority of cases, a ventricular arrhythmia is described, with ventricular fibrillation identified
  • Genetic determination not applicable
    Function/system disorder cardiovascular
    Type disease
  • mutations leading to a disruption of Ca2+/calmodulin (CaM)-dependent inactivation of L-type Ca2+ channels (PMID: 27765793))