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GENATLAS PHENOTYPE
last update : 24-11-2010
Symbol LPRS5
Location 4p14
Name leprosy, susceptibility locus 5
Other name(s) leprosy, protection against
Corresponding gene TLR1
Main clinical features TLR1 N248S polymorphism has been shown to diminish TLR1 signaling and subsequent leprosy disease (PMID: 19456232))
Genetic determination
Function/system disorder defense and immunity
Type susceptibility factor
Mechanism(s)
Gene mutationChromosome rearrangementEffectComments
other     N248S polymorpism,the homozygous genotype SS was more frequent (P=.012) and the heterozygous SN genotype was less frequent (P=.015) in patients with leprosy than in control subjects (PMID: 19456232)
Remark(s) The homozygous genotype SS was more frequent (P=.012) and the heterozygous SN genotype was less frequent (P=.015) in patients with leprosy than in control subjects