Symbol
| LPRS5
|
Location
| 4p14
|
Name
|
leprosy, susceptibility locus 5 |
Other name(s)
|
leprosy, protection against |
Corresponding gene
|
TLR1
|
Main clinical features
|
TLR1 N248S polymorphism has been shown to diminish TLR1 signaling and subsequent leprosy disease (PMID: 19456232)) |
Genetic determination
Function/system disorder
| defense and immunity |
Type
| susceptibility factor
| |
Gene mutation | Chromosome rearrangement | Effect | Comments |
|
---|
other
|  
|  
| N248S polymorpism,the homozygous genotype SS was more frequent (P=.012) and the heterozygous SN genotype was less frequent (P=.015) in patients with leprosy than in control subjects (PMID: 19456232)
| |
Remark(s)
|
The homozygous genotype SS was more frequent (P=.012) and the heterozygous SN genotype was less frequent (P=.015) in patients with leprosy than in control subjects |