Home Page
References OMIM Gene GeneReviews HGMD HGNC
GENATLAS PHENOTYPE
last update : 13/07/2006
Symbol IMT
Location 2p23
Name inflammatory myofibroblastic tumor
Corresponding gene ALK
Main clinical features neoplasm composed of myofibroblastic spindle cells and infiltrating inflammatory cells
Genetic determination
Function/system disorder connective tissue
neoplasia
Type malignancy
Gene product
Name chimeric transcripts
Mechanism(s)
Gene mutationChromosome rearrangementEffectComments
  translocation   a subgroup of IMT, in particular among children and young adults, harbors clonal chromosomal rearrangements involving chromosome band 2p23.
  translocation   (t(2;4)(p23;q21)with SEC31L1/ALK fusion gene
Remark(s) these acquired rearrangements target the ALK gene, serving as the 3 prime-partner in fusion genes with various translocation partners