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GENATLAS PHENOTYPE

last update : 13/07/2006

Symbol	IMT
Location	2p23
Name	inflammatory myofibroblastic tumor
Corresponding gene	ALK
Main clinical features	neoplasm composed of myofibroblastic spindle cells and infiltrating inflammatory cells
Genetic determination
Function/system disorder	connective tissue
	neoplasia
Type	malignancy

Gene product

Name	chimeric transcripts

Mechanism(s)

Gene mutation	Chromosome rearrangement	Effect	Comments
	translocation		a subgroup of IMT, in particular among children and young adults, harbors clonal chromosomal rearrangements involving chromosome band 2p23.
	translocation		(t(2;4)(p23;q21)with SEC31L1/ALK fusion gene

Remark(s)

these acquired rearrangements target the ALK gene, serving as the 3 prime-partner in fusion genes with various translocation partners