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References OMIM Gene GeneReviews HGMD HGNC
last update : 28-11-2018
Symbol HTSS4
Location 12q13.13
Name hypotrichosis simplex of the scalp 4
Other name(s) Hypotrichosis 3
Corresponding gene KRT74
Other symbol(s) HYPT3, HTSS2
Main clinical features
  • normal hair at birth; but progressive, gradual loss of scalp hair beginning at the middle of the first decade and leading to almost complete loss of scalp hair by the third decade
  • body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally
  • Genetic determination autosomal dominant
    Function/system disorder dermatology
    Type disease