in addition to the colon (most often the right side), organs commonly affected with cancer include the endometrium, stomach, biliary and pancreatic system, and urinary tract
DNA mismatch repair protein MSH6
over 30 mutations identified
susceptibility to HNPCC/Lynch syndrome have been convincely linked to mutations in four MMR genes: MSH2 (~50 percent), MLH1(~40 percent), MSH6(~10 percent), and PMS2. Clinical significance of mutations in MLH3 and PMS1 are less clear.