Home Page
Orphanet References OMIM Gene GeneReviews HGMD HGNC
last update : 12/12/2008
Symbol HBA1
Location 16p13.3
Name hydrops fetalis (HB-A@ deletion)
Corresponding gene HB-A@
related resource A Syllabus of Human Hemoglobin Variants & A Syllabus of Thalassaemia Mutations
Main clinical features
  • in southeast Asia, alpha-thalassemia the most common cause of fetal hydrops
  • because alpha-globin chains normally are produced throughout gestation, fetuses without alpha-globin genes would suffer from severe anemia, and thus hypoxia, heart failure, and hydrops fetalis
  • Genetic determination autosomal recessive
    Function/system disorder metabolism/porphyrin and heme
    Type disease
    Gene product
    Name hemoglobin, alpha cluster (HB-A@)