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GENATLAS PHENOTYPE
last update : 14/01/2009
Symbol GTS7
Location 7q31
Name Tourette syndrome, chromosome 7 related
Other name(s) Gilles de la Tourette syndrome
Corresponding gene IMMP2L
Other symbol(s) GTS
Main clinical features
  • neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities
  • Genetic determination
    Function/system disorder
    Type disease
    Mechanism(s)
    Gene mutationChromosome rearrangementEffectComments
      breakpoint   disrupted in 2 cases with reciprocal translocation
    unknown     no mutation found
    Remark(s)
  • candidate gene to be confirmed
  • complex mode of inheritance likely involving contribution of several genes with different effect size
  • other localisations suggested by breakpoints or linkage includes 18q22 (see GTS18), 8p, 4q, 11q23, 8q22, 2p11, 7q31, 17q25, 9q24
  • a gene of major effect could be located on 2p32.2.