| Symbol
| GRL
|
| Location
| 5q31.3
|
| Name
|
cortisol resistance, primary |
| Other name(s)
|
pseudohermaphroditism, female, with hypokalemia, due to glucocorticoid resistance |
| Corresponding gene
|
NR3C1
|
| related resource
| Glucocorticoid receptor resource database
|
| Other symbol(s)
| GCCR, GCR
|
| Main clinical features
|
increased glucocorticoid levels, mineralocorticoid excess resulting in hypertension, hypokalemia, and metabolic alkalosis
impaired response to stress and reduced anxiety
resistance of the hypothalamic-pituitary-adrenal axis to dexamethasone |
| Genetic determination
| autosomal dominant |
| Function/system disorder
| endocrinology |
| Type
| disease
|