| Main clinical features
|
childhood-onset kidney disorder manifest clinically by the nephrotic syndrome, which is characterized by proteinuria, hematuria, hypoalbuminemia, and progressive renal failure
renal biopsy showed segmental or global sclerosis of glomeruli and focal tubular dilatation and atrophy with interstitial fibrosis
electron microscopy showed effacement of the foot processes, microvillus transformation of podocytes, focal thickening and disorganization of the glomerular basement membrane, and focal expansion of the mesangial matrix |