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GENATLAS PHENOTYPE

last update : 4/04/2007

Symbol	FASPS
Location	2q37.3
Name	familial advanced sleep phase syndrome
Corresponding gene	PER2
Main clinical features	early morning awakening and early sleep times
Genetic determination	autosomal dominant
Function/system disorder	psychiatric disorder
Type	disease

Gene product

Name	period (Drosophila) homolog 2

Mechanism(s)

Gene mutation	Chromosome rearrangement	Effect	Comments
missense			S662G mutation resulted in PER2 being hypophosphorylated by casein kinase I (CKI)