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GENATLAS PHENOTYPE
last update : 04-04-2013
Symbol F10D
Location 13q34
Name factor X deficiency
Other name(s) Stuart-Power factor deficiency
Corresponding gene F10
Main clinical features bleeding diathesis, bleeding disorder caused by diverse mutations
Genetic determination autosomal recessive
Function/system disorder hematology
Type disease
Gene product
Name coagulation factor X (F10)
Remark(s)
Genotype/Phenotype correlations
  • Asp409del mutant dramatically altered the conformation of the 185-189 loop and impaired binding of the loop to sodium ions (Na(+) ), diminishing the enzymatic activity of F10 (PMID: 22931370))