| Main clinical features
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onset during the first 3 months of life, characterized by generalized bullae in herpetiform arrangement, with serous and hemorrhagic blisters on any part of the body, but most frequently on the palms and soles, around the mouth, and on the trunk and neck
ultrastructurally, intraepidermal blister formation via cytolysis of the basal cells, preceded by clumping of tonofilaments and attachment of condensed keratin filaments to the hemidesmosomes, is pathognomonic of this disorder |