Symbol
| CYLD
|
Location
| 16q12.1
|
Name
|
familial cylindromatosis |
Other name(s)
|
turban tumor syndrome
Brooke-Spiegler syndrome (OMIM 605041) |
Corresponding gene
|
CYLD
|
Other symbol(s)
| FC, TTS, CMDT, CYLD1, BSS
|
Main clinical features
|
characterized by the development of multiple adnexal skin tumours (especially cylindromas, trichoepitheliomas and spiradenomas) arising from the apocrine
mutations in tumorigenic epidermal cells (carrying previous mutations) increases the aggressiveness of carcinomas, mainly through enhancement of the expression of angiogenic factors, having therefore a key role in epidermal cancer malignancy (PMID: 20838385)) |
Genetic determination
| autosomal dominant |
Function/system disorder
| dermatology |
| neoplasia |
Type
| malignancy
|