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GENATLAS PHENOTYPE
last update : 16/06/2006
Symbol CAN
Location 9q34.13 and 6p23
Name myelodysplastic syndrome, refractory anemia
Corresponding gene NUP214 , DEK
Main clinical features
  • with excess of blasts in transformation (MDS/RAEBT), acute myeloid leukemia (AML), with t(6;9)(p23;q34) translocation
  • Genetic determination
    Function/system disorder hematology
    Type malignancy
    Gene product
    Name chimeric fusion protein (165kD) 5'- DEK - NUP214(CAN) -3'
    Mechanism(s)
    Gene mutationChromosome rearrangementEffectComments
      translocation   acquired t(6;9) associated with aspecific subtype of acute myeloid leukemia
    Remark(s)