| Symbol
| CADO
|
| Location
| 12p13.2
|
| Name
|
coronary artey disease with osteoporosis |
| Corresponding gene
|
LRP6
|
| Main clinical features
|
early coronary disease, metabolic syndrome (hyperlipidemia, hypertension, and diabetes), and osteoporosis |
| Genetic determination
| autosomal dominant |
| Function/system disorder
| cardiovascular |
|
| osteo-articular |
|
| metabolism/lipoprotein-lipid |
| Type
| disease
|
| Gene mutation | Chromosome rearrangement | Effect | Comments |
|
|---|
| missense
|
| abnormal protein/loss of function
| substitutes cysteine for arginine at a highly conserved residue of an epidermal growth factor-like domain, impairs Wnt signaling
| |