Home Page

References

OMIM

Gene

GeneReviews

HGMD

HGNC

GENATLAS PHENOTYPE

last update : 3/07/2006

Symbol	BSSX
Location	Xp11.2 or 18q11.2
Name	synovial sarcoma
Corresponding gene	SS18 , SSX1 , SSX2 , SSX2IP
Other symbol(s)	SSX1, SSRC
Main clinical features	synovial sarcoma
Genetic determination	somatic
Function/system disorder	osteo-articular
	neoplasia
Type	malignancy

Gene product

Name	chimeric fusion protein 5'- SYT - SSX1 - 3' or 5' - SYT - SSX2 - 3', eliminating the KRAB domain of SSX1, SSX2, retaining the repression domain of SSXT

Mechanism(s)

Gene mutation	Chromosome rearrangement	Effect	Comments
	translocation		tumoral, acquired t(X;18)(p11.2;q11.2);

Remark(s)