Main clinical features
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X-linked neurologic disorder characterized by delayed psychomotor development, intellectual disability, and early-onset Parkinson disease; megalencephaly and early-onset parkinsonism
delayed psychomotor development with speech and language delay and persistent frontal lobe reflexes; in the second decade of life, the patients developed extrapyramidal signs, including cogwheel rigidity, tremor, slurred speech, shuffling gait, and postural changes; some patients had choreoathetoid movements |