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GENATLAS PHENOTYPE
last update : 12/06/2006
Symbol BCL1
Location 11q13.2 and 14q32.33
Name leukemia chronic lymphocytic
Corresponding gene CCND1 , IGHG1
Other symbol(s) CLL
Main clinical features
  • leukemia, centrocytic (CC)/intermediate lymphocytic (IDL) primary plasma cell leukemia, mantle cell lymphoma, B cell lymphoma, B cell and multiple myelomas, with translocation t(11;14) (q13;q32), juxtaposing BCL1 to immunoglobin gene (IGH)
    • Genetic determination
    Function/system disorder hematology
    Type malignancy
    Gene product
    Name CCND1 overexpression
    Mechanism(s)
    Gene mutationChromosome rearrangementEffectComments
      translocation   somatic t(11;14) (q13;q32), resulting in CCND1/IGHG1 fusion gene
    Remark(s)