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GENATLAS PHENOTYPE
last update : 28/06/2006
Symbol AZFB
Location Yq11.22
Name nonobstructive spermatogenic failure
Corresponding gene RBMY1A1
Other symbol(s) DELYQ
Main clinical features male infertility characterised by azoospermia/severe oligospermia
Genetic determination genomic disorder
chromosomal
Function/system disorder endocrinology
sex-genitalia
Type disease
Gene product
Name putative testis specific DNA binding protein
Mechanism(s)
Gene mutationChromosome rearrangementEffectComments
  deletion   middle deletion in the D13-D16 interval, not definitely proved as causal
Remark(s) the classical AZF deletions represent only a subset of rearrangements in Yq11