Home Page
References OMIM Gene GeneReviews HGMD HGNC
last update : 02-10-2009
Symbol ATFB6
Location 1p36.22
Name atrial fibrillation, familial, 6
Corresponding gene NPPA
Main clinical features
  • atrial fibrillation at a mean age of 40 years
  • transition from paroxysmal to chronic atrial fibrillation or to arrest of atrial activation, suggesting progressive electrical remodeling
  • Genetic determination autosomal dominant
    Function/system disorder cardiovascular
    Type susceptibility factor
    Remark(s) heterozygous frameshift mutation causing a 12-amino acid extension to the C terminus of NPPA associated to ATFB6 (haves only minor effects on natriuretic peptide receptor interactions but markedly modifies peptide proteolysis) (Dickey 2009)