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GENATLAS PHENOTYPE

last update : 27-02-2009

Symbol	ATFB3
Location	11p15.5
Name	atrial fibrillation, familial, 3
Corresponding gene	KCNQ1
Other symbol(s)	ATFB, FAF2
Main clinical features	the most common sustained cardiac rhythm disturbance, with the most dreaded complication, the thromboembolic stroke cardiac disorder characterized by supraventricular tachyarrhythmia due to uncoordinated atrial activation, a rapid atrial rate of 150–300 beats/min, absence of P waves, presence of rapid oscillations or fibrillatory waves (f waves), and inconsistent R-R intervals on electrocardiograms (ECG)
Genetic determination	autosomal dominant
Function/system disorder	cardiovascular
Type	disease

Gene product

Name	potassium voltage-gated KQT-like subfamily, member 1

Remark(s)