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GENATLAS PHENOTYPE

last update : 22/02/2008

Symbol	APLZF
Location	11q23.1
Name	acute promyelocytic leukemia (APL), zinc finger
Corresponding gene	ZBTB16
Other symbol(s)	PLZF, ZNF145
Genetic determination
Function/system disorder	hematology
Type	malignancy

Gene product

Name	chimeric fusion protein 5' - ZNF145 - RARA - 3', mediating leukemogenesis through aberrant chromatin acetylation via the binding of the chimeric protein to the histone deacetylase (HD) recruiting nuclear co-repressor in a ligand dependent manner

Genotype/Phenotype correlations

with translocation t(11;17)(q23;q12)