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References OMIM Gene GeneReviews HGMD HGNC
last update : 22/02/2008
Symbol APLZF
Location 11q23.1
Name acute promyelocytic leukemia (APL), zinc finger
Corresponding gene ZBTB16
Other symbol(s) PLZF, ZNF145
Genetic determination
Function/system disorder hematology
Type malignancy
Gene product
Name chimeric fusion protein 5' - ZNF145 - RARA - 3', mediating leukemogenesis through aberrant chromatin acetylation via the binding of the chimeric protein to the histone deacetylase (HD) recruiting nuclear co-repressor in a ligand dependent manner
Genotype/Phenotype correlations with translocation t(11;17)(q23;q12)