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last update : 24/1/1997
Symbol AMLM4EO
Location 16p13 and 16q22
Name acute myelomonocytic leukemia with bone marrow eosinophilia
Corresponding gene CBFB , MYH11
Main clinical features
  • a subtype of AML with distinct morphological features . Inversion (16)(p13.1q22), t(16;16)(p13.1;q22), and del(16)(q22) are nonrandom abnormalities associated with AML M4Eo and a favorable prognosis, compared with the standard risk group for AML
  • Genetic determination
    Function/system disorder hematology
    Type malignancy
    Gene product
    Name chimeric fusion protein 5'- CBFB - MYH11 -3'
    Gene mutationChromosome rearrangementEffectComments
      inversion   acquired inv(16)(p13q22)
      translocation   acquired t(16;16)
      translocation   other translocations