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References OMIM Gene GeneReviews HGMD HGNC
last update : 12-12-2012
Symbol ALS8
Location 20q13.32
Name familial amyotrophic lateral sclerosis 8
Corresponding gene VAPB
Main clinical features
  • neurodegenerative disorder characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis
  • progressive muscular atrophy, progressive bulbar palsy, onset occuring between 31 and 45 years and slow progression
  • muscular atrophy and weakness, accompanied by fasciculation and spasticity, and a rapid and progressive degeneration of motor neurons in the cortex, brainstem and spinal cord
  • Genetic determination autosomal dominant
    Function/system disorder neurology
    Type disease
    Gene product
    Name VAMP (vesicle-associated membrane protein)-associated protein B and C, missense mutation