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GENATLAS PHENOTYPE

last update : 29-08-2023

Symbol	ALS25
Location	12q13.3
Name	amyotrophic lateral sclerosis 25
Corresponding gene	KIF5A
Main clinical features	neurodegenerative disorder clinically characterized by rapidly progressive muscle weakness and death due to respiratory failure, with a lower median age at onset (46.5 years) and longer median survival (10 years) than others ALS adult onset of focal asymmetric involvement of upper and lower motor neuron systems with later generalization, bulbar motor involvement, rapid disease progression
Genetic determination	autosomal dominant
Function/system disorder	neurology
Type	disease

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