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References OMIM Gene GeneReviews HGMD HGNC
last update : 14-12-2013
Symbol ALS18
Location 17p13.2
Name amyotrophic lateral sclerosis 18
Corresponding gene PFN1
Main clinical features
  • neurodegenerative disorder characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis
  • limb onset, and age of onset for familial ALS18 cases was 44.8 +/- 7.4 years
  • Genetic determination autosomal dominant
    Function/system disorder neurology
    Type disease