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GENATLAS PHENOTYPE

last update : 23/12/2008

Symbol	ALCL
Location	2p23
Name	ALK-positive anaplastic large-cell lymphoma
Corresponding gene	ALK
Genetic determination	other
Related entries	IMT
Function/system disorder	neoplasia
	hematology
Type	malignancy

Gene product

Name	chimeric transcripts

Mechanism(s)

Gene mutation	Chromosome rearrangement	Effect	Comments
	translocation		most of the ALK-positive ALCL are characterized by the presence of the NPM-ALK fusion protein, the product of the t(2;5)(p23;q35)
	translocation		10-20 percent of ALCL contain variant ALK fusions, including ATIC-ALK, TFG-ALK, CLTC-ALK (previously designated CLTCL-ALK), TMP3-ALK, MSN-ALK and others

Remark(s)

acquired chromosomal rearrangements