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GENATLAS PHENOTYPE

last update : 13-01-2022

Symbol	AGM8
Location	19p13.3
Name	agammaglobulinemia 8, autosomal dominant
Corresponding gene	TCF3
Main clinical features	in the first years of life, severe infections, including pneumococcal meningitis, recurrent otitis, vaccine-associated polio, and arthritis laboratory studies showed severely decreased levels of serum immunoglobulins and less than 3p100 of CD19+ circulating B cells bone marrow biopsy showed a severe reduction in the number of pro- and pre-B cells
Genetic determination	autosomal dominant
Function/system disorder	defense and immunity
Type	disease

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