most common form of glomerulonephritis
. onset before the age of 40 years with hematuria and proteinuria and a progressive renal failure in 30 percent of patients
. incomplete penetrance, heterogeneous
kidney and urinary tract
evidence of linkage to multiple chromosomal regions was considered consistent with both an oligo/polygenic and a multiple susceptibility gene model for familial IGAN, with small or moderate effects in determining the pathologic phenotype.