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GENATLAS PHENOTYPE

last update : 13/07/2006

Symbol	IGAN1
Location	6q22-q23
Name	IgA nephropathy
Other name(s)	Berger disease
Main clinical features	most common form of glomerulonephritis . onset before the age of 40 years with hematuria and proteinuria and a progressive renal failure in 30 percent of patients . incomplete penetrance, heterogeneous
Genetic determination	autosomal dominant
Related entries	IGAN2, IGAN3
Function/system disorder	kidney and urinary tract
Type	susceptibility factor

Remark(s)

evidence of linkage to multiple chromosomal regions was considered consistent with both an oligo/polygenic and a multiple susceptibility gene model for familial IGAN, with small or moderate effects in determining the pathologic phenotype.