basic FUNCTION
| regulator of matrix remodeling |
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playing an essential role in normal dental enamel development |
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degradation of amelogenin (component of tooth enamel) |
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involved in the process of tooth enamel formation |
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principle functions of MMP20 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins |
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enzyme that processes ameloblastin during the secretory stage of amelogenesis |
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cleaves CDH1 and influences ameloblast development |
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over-expression of MMP20 results in decreased enamel hardness, and likely few feedback controls are present in the enamel matrix to prevent excessive MMP20 activity |
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MMP20 and KLK4 serve overlapping and complementary functions to harden enamel by removing protein, but MMP20 potentially serves multiple additional functions necessary for the adherence of enamel to dentin and the release of intercellular protein stores into the enamel matrix |
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ameloblasts responsible for enamel formation express MMP20, an enzyme that cleaves enamel matrix proteins, including amelogenin (AMELX) and ameloblastin (AMBN) |
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increased MMP20 activity in molars causes premature degradation of ameloblastin and inactivation of cofilin, which may contribute to pathological Wnt-mediated cell migration away from the enamel layer |
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proteolysis of extracellular enamel matrix proteins by MMP20 is not required for the initial development of the enamel rod structure during the early secretory stage of amelogenesis, but proteolysis by MMP20, however, is essential for the prevention of abnormal crystal formation during amelogenesis |
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MMP20 function during dentin formation |