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Symbol ZYX contributors: mct - updated : 22-02-2015
HGNC name zyxin
HGNC id 13200
Location 7q34      Physical location : 143.078.359 - 143.088.202
Synonym name
  • component of cell junction matrix,concentrated at adhesion plaques and along actin-filament bundles
  • zyxin-2
  • Synonym symbol(s) ESP-2, HED-2
    TYPE functioning gene
    STRUCTURE 9.85 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    EPHB6 7q33-q35 EphB6 TRPV6 7q33-q34 transient receptor potential cation channel, subfamily V, member 6 TRPV5 7q35 transient receptor potential cation channel, subfamily V, member 5 C7orf34 7q35 chromosome 7 open reading frame 34 KEL 7q33 Kell blood group LOC135924 7q35 similar to Olfactory receptor 9A2 LOC346517 7q35 similar to Olfactory receptor 6V1 sdolf 7q35 olfactory receptor sdolf PIP 7q34 prolactin-induced protein TAS2R39 7q35 taste receptor, type 2, member 39 TAS2R40 7q35 taste receptor, type 2, member 40 LOC51064 7q35 glutathione S-transferase subunit 13 homolog FLJ90586 7q35 hypothetical protein FLJ90586 CASP2 7q34-q35 caspase 2, apoptosis-related cysteine protease (neural precursor cell expressed, developmentally down-regulated 2) LOC346521 7q35 similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) CLCN1 7q35 chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) KIAA0773 7q35 chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) LOC202775 7q35 hypothetical LOC202775 ZYX 7q34-q35 zyxin EPHA1 7q32-q34 EphA1 TAS2R62P 7q35 taste receptor, type 2, member 62 pseudogene TAS2R60 7q35 taste receptor, type 2, member 60 TAS2R41 7q35 taste receptor, type 2, member 41 LOC392132 7 similar to olfactory receptor MOR257-1 LOC392133 7 similar to seven transmembrane helix receptor LOC392134 7 similar to 60S ribosomal protein L26 LOC392135 7 similar to Multifunctional protein ADE2 FLJ40722 7q35 hypothetical protein FLJ40722 MGC41943 7q35 hypothetical protein MGC41943 LOC392136 7 similar to Multifunctional protein ADE2 LOC392137 7 similar to 60S ribosomal protein L26 KIAA0738 7q35 similar to 60S ribosomal protein L26
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2325 - 572 - 2005 15748890
    10 - 2322 - 572 - 2005 15748890
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemovary  highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    at STAGE
  • a N terminal proline rich region
  • a nuclear export signal
  • a LIM domain region playing a major role in regulating zyxin function in cell–cell adhesion, and acting as a negative regulatory element in controlling zyxin function , and localizes to cell–cell adhesion via AAs 230–280 of the central hinge region
  • three C terminal cysteine-rich LIM/double zinc finger motifs, recruiting zyxin to force-bearing sites at the leading edge of migrating cells
  • conjugated PhosphoP
  • zyxin/ajuba family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
  • colocalizes with HIPK2 at the cytoskeleton and in the cell nucleus
  • localizes to the sites of cell-cell adhesion and is thought to promote actin assembly with ENAH/VASP
  • basic FUNCTION
  • involved in the spatial control of actin assembly and in communication between the adhesive membrane and the cell nucleus
  • involved in mechanical-force-dependent facilitation of actin polymerization at focal adhesions
  • may play an important role in the organization of focal adhesions with LASP1 and NEBL
  • required for the reorganization of actin fibers and migration of the endocardial cells (reorganizes actin fibers and enhances cell motility in response to TGF-beta1, thereby regulating EMT)
  • possible ZYX functions in morphogenetic rearrangements, maintaining collective migration by transducing individual cells' movements through adherens junctions, thus preventing the dissociation of individual migratory cells
  • ZYX mediation of stretch-induced gene expression in human endothelial cells
  • key regulator of actin assembly because zyxin recruits Enabled/vasodilator-stimulated phospho-proteins (ENAH/VASP) to promote actin assembly
  • having tumor suppressor activity in Ewing tumor cells
  • actin regulatory protein that is concentrated at sites of actin–membrane association, particularly cell junctions
  • novel regulator of the HIPK2-TP53 signaling axis in response to DNA damage
  • potential role for Zyxin in DNA damage-induced cell fate control through modulating the HIPK2-TP53 signaling axis
  • is a regulator of Hippo signaling, thus also raising the possibility that mechanical strain could be linked to the regulation of gene expression and growth through Hippo signaling
  • focal adhesion protein that responds to external mechanical forces
  • stabilizes DHX58 and MAVS interactions and promotes type I interferon response
    a component
  • zyxin constituent of cell junction matrix
    small molecule
  • interacting with NEBL and LASP1 (SH3 domains from LASP1 and nebulin can also interact with zyxin, but the SH3 domains from more distantly related proteins such as vinexin and SNX9 do not)
  • interaction partner for synemin
  • by recruiting VASP, zyxin regulates actin assembly at the sites of force-bearing cell-cell adhesion
  • participates in regulation of actin dynamics by binding to VASP, an interaction that occurs through a series of four proline-rich repeats at the N-terminus of the zyxin sequence
  • ZYX–PVRL2 interaction plays a critical role in zyxin targeting to these sites
  • novel functional target and effector of TGFB signaling in lung cancer
  • ZYX serves as a scaffold for the interactions between DHX58 and MAVS
  • cell & other
    activated by in the nucleus by thymosin beta4 (TMSB4X)
    Other zyxin phosphorylation prevents zyxin head–tail and suggests how the loss of the regulatory head–tail interaction alters zyxin function at cell–cell junctions
    corresponding disease(s)
    Variant & Polymorphism
    Candidate gene
    Therapy target
    LIM-domain protein Zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo