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FLASH GENE
Symbol ZYG11B contributors: mct - updated : 28-05-2020
HGNC name zyg-11 homolog B (C. elegans)
HGNC id 25820
Location 1p32.3      Physical location : 53.192.130 - 53.293.011
Synonym name zyg-11 homolog B
Synonym symbol(s) ZYG11, FLJ13456, KIAA1730
DNA
TYPE functioning gene
STRUCTURE 100.88 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 8143 84 744 - 2016 27810909
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   predominantly
Digestiveliver    
Lymphoid/Immunethymus    
Reproductivefemale systembreastmammary gland  
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ARM-like domain
  • HOMOLOGY
    interspecies ortholog to dog LOC482495
    ortholog to murine D6Bwg1452e
    Homologene
    FAMILY
  • zyg-11 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • ZYG11B and ZER1 were found to participate in the quality control of N-myristoylated proteins, in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTCH1 intracellular domain (ICD7) interacted with most components of the CUL2 (CUL2)-based E3 ligase complex, including ELOC, ELOB, ZYG11B, and CUL2 itself
  • ZFP36L2 protein was eliminated after release from M phase, and ZYG11B-based E3 ligase plays a role in its polyubiquitination in interphase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS