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FLASH GENE
Symbol ZXDC contributors: mct/npt - updated : 10-04-2015
HGNC name ZXD family zinc finger C
HGNC id 28160
Location 3q21.2      Physical location : 126.156.444 - 126.194.762
Synonym name ZXD-like zinc finger protein
Synonym symbol(s) FLJ13861, MGC11349, ZXDL
DNA
TYPE functioning gene
STRUCTURE 38.32 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3410 90 858 - Al-Kandari (2007)
- - 4888 - 710 - Al-Kandari (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunespleen   highly
Reproductivefemale systemuteruscervix  
 female systembreastmammary gland  
 male systemprostate  highly
Respiratorylung    
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten C2H2-type zinc fingers
  • a transcriptional activation domain
  • HOMOLOGY
    interspecies ortholog to murine Zxdc
    Homologene
    FAMILY
  • zinc finger family
  • zinc finger X-linked duplicated family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role as an important regulator of both MHC class I and class II transcription
  • with ZXDA form an important regulatory complex for MHC II gene transcription (AlKandari 2007)
  • sumoylation is required for full activity of the transcriptional activation domain (Jambunathan 2007)
  • regulates genes involved in myeloid cell differentiation and inflammation
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with CIITA (interact with the region of CIITA containing leucine-rich repeats)
  • is a regulator in the process of myeloid function and is responsible for CCL2 gene de-repression by BCL6
  • cell & other
    REGULATION
    Other regulated by sumoylation (important regulator of ZXDC) (Jambunathan 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS