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FLASH GENE
Symbol ZXDA contributors: mct/npt - updated : 30-06-2008
HGNC name zinc finger, X-linked, duplicated A
HGNC id 13198
Location Xp11.21      Physical location : 57.931.865 - 57.937.067
Synonym name zinc finger X-linked protein ZXDA
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 2.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
APEX2 Xp11.22 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 ALAS2 Xp11.21 aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) LOC389860 X similar to PAGE-5 protein LOC203569 Xp11.22 similar to PAGE-5 protein LOC90736 Xp11.22 hypothetical protein BC000919 PAGE-5 Xp11.22 PAGE-5 protein LOC139793 Xp11.22 similar to XAGE-5 protein MAGEH1 Xp11.22 APR-1 protein LOC158880 LOC392474 X similar to hypothetical protein MGC21658 Xp11.22 similar to Forkhead box protein N4 LOC392475 X similar to XAGE-5 protein RRAGB Xp11.21 Ras-related GTP binding B LOC392476 X similar to Got2-prov protein KLF8 Xp11.21 Kruppel-like factor 8 UBQLN2 Xp11.23-p11.1 ubiquilin 2 LOC389861 X LOC389861 LOC169981 Xp11.22 hypothetical protein LOC169981 SPIN2 Xp11.23-p11.21 hypothetical protein LOC169981 FLJ31204 Xp11.21 hypothetical protein FLJ31204 LOC389862 X similar to Zinc finger X-linked protein ZXDB NOD24 Xp11.21 NOD24 pseudogene LOC392477 X similar to cytosolic malate dehydrogenase ZXDA Xp11.21 zinc finger, X-linked, duplicated A LOC392478 X similar to L-myc-1 proto-oncogene protein LOC392479 X similar to keratin 8, type II cytoskeletal - human
regionally located located within approximately 400 kb of ZXDB
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2886 84.8 799 - Al-Kandari (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Reproductivefemale systemplacenta   
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C2H2 type-zinc finger domain
  • a domain organization similar to ZXDC, containing ten zinc fingers
  • a transcriptional activation domain
  • HOMOLOGY
    interspecies homolog to C.elegans ZK1248.3
    Homologene
    FAMILY
  • zinc finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • with ZXDC form an important regulatory complex for MHC II gene transcription (AlKandari 2007)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting wirh ZXDC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS