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FLASH GENE
Symbol ZWINT contributors: mct - updated : 17-12-2014
HGNC name ZW10 interactor
HGNC id 13195
Location 10q21.1      Physical location : 58.117.198 - 58.121.034
Synonym name ZW10 interacting protein-1
Synonym symbol(s) HZwint-1, KNTC2AP, MGC117174, ZWINT1, KRE28p
DNA
TYPE functioning gene
STRUCTURE 4.05 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1687 31 277 - 2008 18268100
8 - 1878 - 277 - 2008 18268100
9 - 1546 - 230 - 2008 18268100
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousbrain   highly Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,chromatin/chromosome,kinetochore
text
  • associated with the kinetochore
  • with NDC80, co-localize at kinetochores beginning at prophase and ZW10 joins them later at prometaphase
  • ZWINT localizes to the kinetochore in prophase, before ZW10 localization, and remains at the kinetochore until anaphase, after ZW10 has dissociated
  • basic FUNCTION
  • required for stable association of CENPF and dynamitin but not BUB1 with the kinetochore
  • new component of the mitotic checkpoint
  • essential for kinetochore binding by components of the spindle assembly checkpoint
  • role for the kinetochore protein ZWINT in presynaptic events that are regulated by RAB3A, RAB3B, RAB3C and SNAP25
  • RAB3 specific binding protein that bound preferentially to RAB3C
  • kinetochore protein having a role in presynaptic events that are regulated by RAB3C and SNAP25
  • is a structural protein, part of the inner kinetochore scaffold and recruits ZW10 to the kinetochore
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis
  • transiently forms complexes with NDC80 and ZW10 in a temporal and spatial manner
  • exhibit an E3 ubiquitin ligase activity and undergo self-ubiquitination
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ZW10 (specifies the kinetochore association of ZW10 by interacting with its N-terminal domain
  • ZWINT is critical for recruiting ZW10 to unattached kinetochores
  • ZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with ZWINT, and is essential for mitotic checkpoint arrest
  • RAB3 specific binding protein that bound preferentially to RAB3C
  • kinetochore protein known to interact with the kinetochore checkpoint protein ZW10
  • novel AURKB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase
  • TRIM17 interacted with ZWINT and overexpression of TRIM17 caused down-regulation of protein levels of ZWINT in mammalian cells
  • cell & other
    REGULATION
    Phosphorylated by AURKB
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS