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FLASH GENE
Symbol ZSCAN4 contributors: mct - updated : 25-04-2017
HGNC name zinc finger and SCAN domain containing 4
HGNC id 23709
Location 19q13.43      Physical location : 58.180.302 - 58.190.519
Synonym name zinc finger protein 494
Synonym symbol(s) FLJ35105, ZNF494, MGC126787, MGC126789
DNA
TYPE functioning gene
STRUCTURE 10.20 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2260 48.8 433 - 2004 15231748
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousspinal cord    
Reproductivefemale systemovary    Mus musculus
 male systemtestis    Mus musculus
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatocyte Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four C2H2-type zinc fingers
  • SCAN box domain
  • HOMOLOGY
    Homologene
    FAMILY
  • zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • co-localization of ZSCAN4 and TERF1 to the nucleus
  • basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • ZSCAN4 plays an important role independent of telomere maintenance pathways (telomerase positive and ALT) or cell lineage
  • plays a key role in genomic stability by regulating telomere elongation
  • DNA-binding protein that functions for telomere elongation and genomic stability
  • ZSCAN4 may play critical roles during late meiotic prophase in both males and females
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • RIF1 is required to maintain telomere length homeostasis by negatively regulating ZSCAN4 expression
  • functions as a mediator of telomere length through its direct interaction with RAP1A, possibly regulating shelterin complex-controlled telomere elongation in both telomerase positive and alternative lengthening of telomere pathways
  • interaction of ZSCAN4 with TERF1 functions in regulation of telomere elongation in ESC
  • binds to TERF1 in cancer cells to function in regulating telomere length
  • cell & other
    REGULATION
    repressed by RIF1 that negatively modulates ZSCAN4 expression by maintaining H3K9me3 levels at subtelomeric regions
    Other activated during the diplotene/dictyate stage in meiotic prophase I
    is activated to recover shortened telomeres during extended cell cycles, irrespective of the pluripotent status
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS