basic FUNCTION
| ATP-dependent annealing helicase, with annealing helicase activity but lacking any detectable DNA unwinding activity |
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catalyzes the ATP-dependent relaxation of the RPA-unwound DNA, as observed with SMARCAL1 |
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maintains genomic stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events |
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a unique structure-specific endonuclease activity, which is coupled to ATP hydrolysis |
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role for ZRANB3 in the replication stress response and suggest new insights into how DNA repair is coordinated with DNA replication to maintain genome stability |
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ZRANB3 can recognize K63-linked polyubiquitinated PCNA and plays an important role in restarting stalled replication forks |
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functions in PCNA binding and remodeling of stalled replication forks at the DNA damage sites |