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FLASH GENE
Symbol ZRANB3 contributors: mct - updated : 09-09-2015
HGNC name zinc finger, RAN-binding domain containing 3
HGNC id 25249
Location 2q21.3      Physical location : 135.957.575 - 136.288.806
Synonym name
  • annealing helicase 2
  • Synonym symbol(s) FLJ38043, MGC75012, AH2
    DNA
    TYPE functioning gene
    STRUCTURE 331.23 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3717 97 1079 - 2010 21078962
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved SNF2 helicase domain
  • a HARP-like (HPL) domain in ZRANB3 that is indispensible for its annealing activity
  • an HNH motif in its C-terminal region (only vertebrate protein with an HNH motif)
  • HOMOLOGY
    Homologene
    FAMILY
  • annealing helicase, ATP-driven DNA-rewinding motor proteins family
  • SNF2 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • localizes to DNA replication sites and interacts with the components of the replication machinery
  • basic FUNCTION
  • ATP-dependent annealing helicase, with annealing helicase activity but lacking any detectable DNA unwinding activity
  • catalyzes the ATP-dependent relaxation of the RPA-unwound DNA, as observed with SMARCAL1
  • maintains genomic stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events
  • a unique structure-specific endonuclease activity, which is coupled to ATP hydrolysis
  • role for ZRANB3 in the replication stress response and suggest new insights into how DNA repair is coordinated with DNA replication to maintain genome stability
  • ZRANB3 can recognize K63-linked polyubiquitinated PCNA and plays an important role in restarting stalled replication forks
  • functions in PCNA binding and remodeling of stalled replication forks at the DNA damage sites
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZRANB3 is recruited by polyubiquitinated PCNA to promote fork restart following replication arrest
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in mammalian cells results in an increased frequency of sister chromatid exchange and DNA damage sensitivity after treatment with agents that cause replication stress
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS