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FLASH GENE
Symbol ZRANB2 contributors: mct/npt/pgu - updated : 25-05-2011
HGNC name zinc finger, RAN-binding domain containing 2
HGNC id 13058
Location 1p31      Physical location : 71.528.974 - 71.546.972
Synonym name
  • zinc finger protein 265
  • zinc finger, splicing
  • Synonym symbol(s) ZIS, ZIS1, ZIS2, ZNF265, FLJ41119, DKFZp686N09117, DKFZp686J1831
    DNA
    TYPE functioning gene
    STRUCTURE 17.99 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D1S203 - D1S2866 - D1S2754 - PDE4B - D1S198 - D1S2806 - RPE65 - CTH - D1S501 - PTGER3 - D1S411 - D1S448 - ZNF165 - ACADM ACADM - RABGGTB - D1S481 - D1S216 - D1S2618 - D1S500 - D1S2856 - D1S207 - D1S488 - D1S2766 - D1S2865 - qter
    Authors LDB, GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    text alternatively spliced to give two variants with different 3prime ends (PMID: 17905639)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3087 38.2 337 ubiquitous 2008 17905639
    lacking exon 10, larger exon 11
    11 - 3162 - 311 - 2008 17905639
    - - - 5200 - - ubiquitous 1998 9931435
    - - - 3900 - - fetal brain, kidney 1998 9931435
    - - - 1900 - - fetal brain, kidney 1998 9931435
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunethymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines monoblast cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two RanBP2-type zinc fingers (ZnF), binding to a single AGGUAA motif and the 2 domains combine to recognize AGGUAA(Nx)AGGUAA double sites (Loughlin 2009), containing four highly conserved cysteine residues, and forming a stable, monomeric structure
  • a nuclear localization signal (NLS)
  • Asp-Glu and a Ser-Arg rich regions, arginine/serine-rich (RS) domains
  • a zinc coordinating DNA binding domain
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family
  • ZRANB2 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potential regulator of transcription and/or splicing
  • involved in the regulation of cell morphogenesis or cell identity
  • splice factor required for alternative splicing of SFRS10/TRA2B transcripts
  • can regulate alternative splicing but lacks canonical RNA-binding domains
  • might act by binding directly to a subset of 5prime splice sites so as to prevent recognition of those sites by the spliceosome
  • CELLULAR PROCESS nucleotide, transcription, maturation
    nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text hematopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binds to mRNA, as well as the essential splicing factors SNRNP70 and U2AF1 and the novel splicing component AKAP17A
  • interacts with the spliceosomal proteins SNRNP70, and U2AF1 (can acts early in the splicing reaction, consistent with a role in splice site choice)
  • RanBP2-type zinc finger (ZnF) domains from ZRANB2 can bind to a sequence containing the consensus AGGUAA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS