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FLASH GENE

Symbol

ZP4

contributors: mct - updated : 18-10-2017

HGNC name	zona pellucida glycoprotein 4
HGNC id	15770

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q43      Physical location : 238.041.163 - 238.054.222
Synonym name	zona pellucida B protein
Synonym symbol(s)	ZBP, ZP1, ZPB, ZBP, Zp-4

DNA

TYPE	functioning gene
STRUCTURE	13.06 kb     12 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021186 13 - 2474 NP_067009 - 540 - 2015 26329136

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive oocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal signal peptide sequence
	a conserved ZP domain, a signature domain comprised of approximately 260 amino acid (aa) residues, that has functional activity and may have a role during fertilization
	a consensus furin cleavage site
	and a C-terminal transmembrane domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	promote acrosomal exocytosis and now establish an additional role for these components as modifiers of sperm motility
	inducing acrosomal exocytosis through a Gi independent pathway
	glycoprotein which is a part of the extracellular matrix of oocyte
	ZP1, ZP3, and ZP4 have been shown to bind to the capacitated human sperm, and acrosome reaction can be mediated by ZP1, ZP3, and ZP4

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ZP1 in addition to ZP3 and ZP4, binds to capacitated spermatozoa and induces acrosomal exocytosis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   is highest among patients with PCOS and a regular cycle, and this is a consequence of the presence of mature follicles in this group constitutional germinal mutation       in some patients with PCOS and infertility

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS