motifs/domains
| N-terminal signal peptide sequence |
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a conserved ZP domain, conserved O-glycosylation domain, a signature domain comprised of approximately 260 amino acid (aa) residues, that has functional activity and may have a role during fertilization |
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ectodomains of ZP2 and ZP3 are sufficient to form the insoluble zona matrix and yet each protein traffics through oocytes without oligomerization |
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a C-terminal consensus furin cleavage site, with the functional activity |
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a transmembrane domain |
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cytoplasmic tails are sufficient and necessary to prevent intracellular oligomerization while ensuring incorporation of processed ZP2 and ZP3 into the zona pellucida |
SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,nucleus
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text
| type I membrane protein, extracellular matrix |
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ZP2 and ZP3 traffic independently, but colocalize at the plasma membrane ( |
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strongly expressed in the nucleus during prophase and gradually translocated to the Zona Pellucida |
basic FUNCTION
| playing a role in sperm-egg recognition |
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promote acrosomal exocytosis and now establish an additional role for these components as modifiers of sperm motility |
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major component of the zona pellucida (ZP) matrix coating mammalian eggs, that is essential for fertilization by acting as sperm receptor |
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ZP1, ZP3, and ZP4 have been shown to bind to the capacitated human sperm, and acrosome reaction can be mediated by ZP1, ZP3, and ZP4 |
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principal component of the zona pellucida (ZP) of mammalian oocytes that is essential for normal fertility |
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oocyte ZP3 expression was the main predictor of the fertilization capacity |
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is a major component of the ZP filament |
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