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FLASH GENE
Symbol ZP3 contributors: mct - updated : 18-10-2017
HGNC name zona pellucida glycoprotein 3 (sperm receptor)
HGNC id 13189
Corresponding disease
OOMD3 oocyte maturation defect 3
Location 7q11.23      Physical location : 76.026.840 - 76.071.387
Synonym name
  • zona pellucida glycoprotein 3A (sperm receptor)
  • zona pellucida glycoprotein 3B
  • Synonym symbol(s) ZP3A, ZP3-424, ZP3-372, ZPC, OOMD3
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE component of a cluster
    STRUCTURE 44.55 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure consisting of an extra G residue in exon 8 compared with ZP3A
    MAPPING cloned Y linked N status confirmed
    Map see POMZP3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1317 - 424 - 2006 16407501
    9 - 1494 - 373 - 2006 16407501
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Reproductivefemale systemuteruscervix highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal peptide sequence
  • a conserved ZP domain, conserved O-glycosylation domain, a signature domain comprised of approximately 260 amino acid (aa) residues, that has functional activity and may have a role during fertilization
  • ectodomains of ZP2 and ZP3 are sufficient to form the insoluble zona matrix and yet each protein traffics through oocytes without oligomerization
  • a C-terminal consensus furin cleavage site, with the functional activity
  • a transmembrane domain
  • cytoplasmic tails are sufficient and necessary to prevent intracellular oligomerization while ensuring incorporation of processed ZP2 and ZP3 into the zona pellucida
  • conjugated GlycoP , Other
    mono polymer heteromer , polymer
    HOMOLOGY
    interspecies homolog to murine Zp3
    homolog to C.elegans y53h1b.1
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text
  • type I membrane protein, extracellular matrix
  • ZP2 and ZP3 traffic independently, but colocalize at the plasma membrane (
  • strongly expressed in the nucleus during prophase and gradually translocated to the Zona Pellucida
  • basic FUNCTION
  • playing a role in sperm-egg recognition
  • promote acrosomal exocytosis and now establish an additional role for these components as modifiers of sperm motility
  • major component of the zona pellucida (ZP) matrix coating mammalian eggs, that is essential for fertilization by acting as sperm receptor
  • ZP1, ZP3, and ZP4 have been shown to bind to the capacitated human sperm, and acrosome reaction can be mediated by ZP1, ZP3, and ZP4
  • principal component of the zona pellucida (ZP) of mammalian oocytes that is essential for normal fertility
  • oocyte ZP3 expression was the main predictor of the fertilization capacity
  • is a major component of the ZP filament
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
  • forming with ZP1 and ZP2 the zona pellicida, in which ZP2 and ZP3 complex into copolymers cross-linked by ZP1
  • component with ZP2 of a complex linked to ZP1 in zone pellucida
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZP1 in addition to ZP3 and ZP4, binds to capacitated spermatozoa and induces acrosomal exocytosis
  • CRISP1 is a multifunctional protein involved not only in sperm-egg fusion but also in the previous stage of sperm-ZP binding through its specific interaction with human ZP3
  • regulates AKT1 phosphorylation, lamin binding to the nuclear membrane via AIPL1, and organization of the actin cytoskeleton via DIAPH2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OOMD3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • female Zp3-deficient mice are completely infertile