motifs/domains
| a N-terminal signal peptide sequence, and N-terminus of ZP2 is the primary sperm-binding ligand |
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a conserved ZP domain, a signature domain comprised of approximately 260 amino acid (aa) residues that has functional activity and may have a role during fertilization |
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a consensus furin cleavage site |
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ectodomains of ZP2 and ZP3 are sufficient to form the insoluble zona matrix and yet each protein traffics through oocytes without oligomerization |
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ZP2(51-149) sperm-binding domain is necessary for gamete recognition and penetration through the zona pellucida |
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and a C-terminal transmembrane domain |
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cytoplasmic tails are sufficient and necessary to prevent intracellular oligomerization while ensuring incorporation of processed ZP2 and ZP3 into the zona pellucida |
SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
text
| ZP2 and ZP3 traffic independently, but colocalize at the plasma membrane ( |