Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZP2 contributors: mct - updated : 18-10-2017
HGNC name zona pellucida glycoprotein 2 (sperm receptor)
HGNC id 13188
Location 16p12.2      Physical location : 21.208.772 - 21.222.868
Synonym name
  • zona pellucida protein A
  • zona pellucida sperm-binding protein 2
  • Synonym symbol(s) ZPA
    DNA
    TYPE functioning gene
    STRUCTURE 17.06 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D16S412 - CRYM - ZP2 - SCNN1B - CDR2 - IL4R - D16S417 - cen
    Authors GeneMap (98),LDB (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2749 - 745 - 2006 16407501
    20 - 2722 - 736 - 2006 16407501
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland highly
     female systemovary  highly Homo sapiens
     male systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal signal peptide sequence, and N-terminus of ZP2 is the primary sperm-binding ligand
  • a conserved ZP domain, a signature domain comprised of approximately 260 amino acid (aa) residues that has functional activity and may have a role during fertilization
  • a consensus furin cleavage site
  • ectodomains of ZP2 and ZP3 are sufficient to form the insoluble zona matrix and yet each protein traffics through oocytes without oligomerization
  • ZP2(51-149) sperm-binding domain is necessary for gamete recognition and penetration through the zona pellucida
  • and a C-terminal transmembrane domain
  • cytoplasmic tails are sufficient and necessary to prevent intracellular oligomerization while ensuring incorporation of processed ZP2 and ZP3 into the zona pellucida
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text ZP2 and ZP3 traffic independently, but colocalize at the plasma membrane (
    basic FUNCTION
  • promote acrosomal exocytosis and now establish an additional role for these components as modifiers of sperm motility
  • functions in secondary binding and penetration of acrosome-reacted spermatozoa
  • mediates secondary sperm binding to the zona pellucida
  • might also play a role in sperm-egg binding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS