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FLASH GENE
Symbol ZNRF1 contributors: mct - updated : 16-05-2018
HGNC name zinc and ring finger 1
HGNC id 18452
Location 16q23.1      Physical location : 75.032.914 - 75.144.892
Synonym name
  • nerve injury 283
  • nerve injury-induced gene 283 protein
  • Synonym symbol(s) NIN283, FLJ14846, MGC15430, DKFZp434E229
    EC.number 6.3.2.-/ 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 111.98 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4633 - 227 - 2009 19737534
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   lowly
    Nervousbrain    
     gangliasensory ganglia   
    Reproductivemale systemtestis  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text cortical plate, highly in developing brain relative to adult
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one zinc finger and one RING finger domain
  • conjugated LipoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Znrf1 (99.1pc)
    Homologene
    FAMILY
  • ZNRF E3 ubiquitin ligases family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • participating in ubiquitin-mediated protein modification
  • may play a role in the establishment and maintenance of neuronal trans mission and plasticity via its ubiquitin-protein ligase activity
  • may mediate regulation of neuritogenesis via interaction with tubulin (Yoshida 2009)
  • mediates potzntially regulation of neuritogenesis via interaction with TUBB2A
  • promotes Wallerian degeneration by targeting AKT1 to degrade through the ubiquitin-proteasome system (UPS)
  • ZNRF1 and ZNRF2 are new players in regulation of the ubiquitous Na(+)/K(+)ATPase that is tuned to changing demands in many physiological contexts
  • is a regulator of TLR4-induced inflammatory responses
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ions Zn2+
  • protein
  • interacting with Tubb2 (Yoshida 2009)
  • TUBB2A is a ZNRF1-binding protein (ZNRF1 interacts with TUBB2A2, suggesting that ZNRF1 is colocalized with TUBB2A)
  • ZNRF1 and ZNRF2 can ubiquitylate the cytoplasmic loop encompassing the nucleotide-binding and phosphorylation regions of the ATP1A1 subunit
  • ZNRF1 promotes Wallerian degeneration by degrading AKT1 to induce GSK3B activation
  • E3 ubiquitin ligase ZNRF1 modulates CAV1 protein stability to regulate Toll-like receptor (TLR) 4-triggered immune responses
  • ZNRF1 is an essential E3 ligase implicated in diverse cellular pathways, and that binds UBE2N
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with deletion of ZNRF1 in their hematopoietic cells display increased resistance to endotoxic and polymicrobial septic shock due to attenuated inflammation