SUBCELLULAR LOCALIZATION
| plasma membrane,junction
|
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,cytoplasm,cytosolic,vesicle
|
basic FUNCTION
| participating in ubiquitin-mediated protein modification |
|
may play a role in the establishment and maintenance of neuronal trans mission and plasticity via its ubiquitin-protein ligase activity |
|
may mediate regulation of neuritogenesis via interaction with tubulin (Yoshida 2009) |
|
mediates potzntially regulation of neuritogenesis via interaction with TUBB2A |
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promotes Wallerian degeneration by targeting AKT1 to degrade through the ubiquitin-proteasome system (UPS) |
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ZNRF1 and ZNRF2 are new players in regulation of the ubiquitous Na(+)/K(+)ATPase that is tuned to changing demands in many physiological contexts |
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is a regulator of TLR4-induced inflammatory responses |