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FLASH GENE
Symbol ZNHIT1 contributors: mct - updated : 18-06-2019
HGNC name zinc finger, HIT type 1
HGNC id 21688
Location 7q22.1      Physical location : 100.860.984 - 100.867.469
Synonym name
  • zinc finger, HIT domain containing 1
  • zinc finger protein, subfamily 4A (HIT domain containing), member 1
  • putative cyclin G1 interacting protein
  • zinc finger protein subfamily 4A member 1 3
  • p18 Hamlet
    Synonym symbol(s) CG1I, H_DJ0747G18.14, ZNFN4A1, CGBP1, p18Hamlet
    DNA
    TYPE functioning gene
    STRUCTURE 6.49 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1208 17.4 154 - Lafarga (2007)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a poly-lys domain
  • one HIT-type zinc finger
  • HOMOLOGY
    interspecies homolog to murine Znhit1
    homolog to rattus LOC360784
    Homologene
    FAMILY
  • ZNHIT1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • plays an important role in stress-induced cell-fate decisions (Cuadrado 2007)
  • ZNHIT1 maintains the interaction between H2AFZ and VPS72 through enhancing VPS72 phosphorylation
  • dominant role of ZNHIT1/H2AFZ in controlling mammalian organ development and tissue homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZNHIT1 has been shown to regulate histone variant H2AFZ deposition, thereby controlling gene transcription
  • ZNHIT1 enhances the interaction between H2AFZ and VPS72
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS