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FLASH GENE
Symbol ZNF76 contributors: - updated : 15-05-2006
HGNC name zinc finger protein 76 (expressed in testis)
HGNC id 13149
Location 6p21.3-p21.2      Physical location : 35.227.509 - 35.263.760
Synonym symbol(s) D6S229E, ZNF523, Zfp523
DNA
TYPE functioning gene
STRUCTURE 36.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see KE@
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
 thyroid   highly
Lymphoid/Immunetonsils   highly
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger protein containing seven zinc finger motifs
  • TBP-interacting region in the C terminus to a glutamic acid-rich domain, acting in a dominant negative manner to enhance Tp53-mediated transactivation
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Xenopus laevis STAF
    intraspecies homolog to ZNF143
    Homologene
    FAMILY zinc finger protein family, C2H2 type,Krüppel-like
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transactivator protein, may be involved in transcriptional regulation
  • functioning as a transcriptional repressor through its interaction with TBP and sumoylation modulates its transcriptional repression activity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • interacting with TBP through both its N and C termini
  • sumoylated by PIAS1 at lysine 411, which is in the minimal TBP-interacting region
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS