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FLASH GENE

Symbol

ZNF74

contributors: - updated : 19-05-2006

HGNC name	zinc finger protein 74 (Cos52)
HGNC id	13144

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q11.21      Physical location : 20.748.479 - 20.762.751
Genatlas name	including ZNF74-1 and ZNF74-2
Synonym symbol(s)	Cos52

DNA

TYPE	functioning gene
STRUCTURE	13.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D22S427 - DGCR6 - PRODH - D22S36 - SLC25A1 - D22S75 - D22S941 - D22S788 - DGCR6 - D22S131 - SERPIND1 - D22S936 - BCR - D22S801 - qter
Authors	Shaikh (00)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ZNF74-1 - splicing 2416 64.1 572 - Aubry ZNF74-2 - splicing - 72.1 643 - Aubry ZNF74-3 - splicing - 68.4 611 - Aubry ZNF74-4 - splicing 3759 64.1 572 - Aubry

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart           vessels           vessels aorta       digestive esophagus         Nervous spinal cord         reproductive respiratory tract

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial barrier/lining endothelium     Epithelial barrier/lining       Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	highly in brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a truncated KRAB Krüppel associated box at the N terminus and twelve zinc finger motifs of the C2H2 Kruppel type at the C terminus

conjugated

MetalloP

HOMOLOGY

interspecies	homolog to Drosophila CG9797
	homolog to C.elegans Y56A3A.16

Homologene

FAMILY

zinc finger protein family,C2H2 type,KRAB subfamily

CATEGORY

RNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	nuclear matrix

basic FUNCTION	potential transcriptional repressor
	playing a role in RNA metabolism

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

nucleic

signaling

RNA metabolism

a component

INTERACTION

DNA

binding

RNA	binding to poly(U) and poly(G) RNAs

small molecule	metal binding,
	zinc Zn2+

protein

cell & other

binding to the nuclear matrix

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS