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FLASH GENE
Symbol ZNF74 contributors: - updated : 19-05-2006
HGNC name zinc finger protein 74 (Cos52)
HGNC id 13144
Location 22q11.21      Physical location : 20.748.479 - 20.762.751
Genatlas name including ZNF74-1 and ZNF74-2
Synonym symbol(s) Cos52
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D22S427 - DGCR6 - PRODH - D22S36 - SLC25A1 - D22S75 - D22S941 - D22S788 - DGCR6 - D22S131 - SERPIND1 - D22S936 - BCR - D22S801 - qter
Authors Shaikh (00)
Physical map
DKFZp761P1121 22q11.21 hypothetical protein DKFZp761P1121 DGCR8 22q11.2 DiGeorge syndrome critical region gene 8 HTF9C 22q11.2 DiGeorge syndrome critical region gene 8 RANBP1 22q11.21 RAN binding protein 1 ZDHHC8 22q11.1 zinc finger, DHHC domain containing 8 LOC388849 22 LOC388849 FLJ32575 22q11.21 hypothetical protein FLJ32575 RTN4R 22q11.21 reticulon 4 receptor LOC388850 22 similar to proline dehydrogenase (oxidase) 1; proline oxidase 2; p53 induced protein; tumor protein p53 inducible protein 6 DGCR6L 22q11.2 DiGeorge syndrome critical region gene 6-like LOC391297 22 LOC391297 LOC284859 22q11.21 hypothetical gene supported by BC039313 GGT2 22q11 gamma-glutamyltransferase 2 LOC284874 22q11.21 hypothetical LOC284874 LOC388851 22 similar to phosphatidylinositol 4-kinase, catalytic, alpha polypeptide isoform 2; phosphatidylinositol 4-kinase, type II, alpha; phosphatidylinositol 4-kinase, type III, alpha; phosphatidylinositol 4-kinase 230 LOC388852 22 similar to hypothetical protein LOC388853 22 similar to Sushi domain (SCR repeat) containing LOC391298 22 similar to KIAA0649 gene product LOC388854 22 similar to Gamma-glutamyltranspeptidase 1 precursor (Gamma-glutamyltransferase 1) (CD224 antigen) LOC388855 22 hypothetical gene supported by BC039313 LOC388856 22 hypothetical gene supported by BC039313 LOC388857 22 similar to KIAA0649 gene product LOC391299 22 similar to Collagen alpha 1(II) chain precursor USP41 22q11.22 ubiquitin specific protease 41 ZNF74 22q11.21 zinc finger protein 74 (Cos52) SCARF2 22q11.21 scavenger receptor class F, member 2 FLJ14360 22q11.21 hypothetical protein FLJ14360 PCQAP 22q11.21 PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein LOC391300 22 similar to hypothetical protein FLJ20297 LOC343839 22q11.21 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) LOC150207 22q11.21 hypothetical gene LOC150207 POM121L4P 22 POM121 membrane glycoprotein-like 4 pseudogene (rat) DKFZp434N035 22q11.21 hypothetical protein DKFZp434N035 PIK4CA 22q11.21 phosphatidylinositol 4-kinase, catalytic, alpha polypeptide SERPIND1 22q11.21 serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 SNAP29 22q11.21 synaptosomal-associated protein, 29kDa CRKL 22q11.21 v-crk sarcoma virus CT10 oncogene homolog (avian)-like FLJ30473 22q11.21-q11.22 hypothetical protein FLJ30473
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2416 64.1 572 - Aubry
- splicing - 72.1 643 - Aubry
- splicing - 68.4 611 - Aubry
- splicing 3759 64.1 572 - Aubry
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vessels    
 vesselsaorta   
digestiveesophagus    
Nervousspinal cord    
reproductiverespiratory tract    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialbarrier/liningendothelium  
Epithelialbarrier/lining   
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a truncated KRAB Krüppel associated box at the N terminus and twelve zinc finger motifs of the C2H2 Kruppel type at the C terminus
conjugated MetalloP
HOMOLOGY
interspecies homolog to Drosophila CG9797
homolog to C.elegans Y56A3A.16
Homologene
FAMILY zinc finger protein family,C2H2 type,KRAB subfamily
CATEGORY RNA associated , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
text nuclear matrix
basic FUNCTION
  • potential transcriptional repressor
  • playing a role in RNA metabolism
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism nucleic
    signaling
    RNA metabolism
    a component
    INTERACTION
    DNA binding
    RNA binding to poly(U) and poly(G) RNAs
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other binding to the nuclear matrix
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS