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FLASH GENE

Symbol

ZNF711

contributors: mct - updated : 09-10-2017

HGNC name	zinc finger protein 711
HGNC id	13128

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease
Location	Xq21.2      Physical location : 84.498.996 - 84.528.366
Synonym name	zinc finger protein 6 (CMPX1)
	dJ75N13.1 (znf6-like)
Synonym symbol(s)	ZNF6, ZNF4, ZNF5, CMPX1, Zfp711, dJ75N13.1, CMPX1, MRX97

DNA

TYPE	functioning gene
STRUCTURE	29.54 kb     9 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - DXS995 - POU3F4 - DXS232 - DXS121 - DXS233 - DXS355 - ZNF6 - DXS326 - DXS1167 - CHM CHM - DXS8326 - DXS1002 - DXS1168 - DXS349 - DXS95 - DXS364 - DXS1196 - DXS262 - DXS110 - DXS1169 - DXS472 - qter
Authors	Villard (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021998 9 - 4182 NP_068838 - 761 - 2011 21384559 NM_001330574 - - 4564 NP_001317503 - 807 - 2011 21384559

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Lymphoid/Immune thymus       highly Reproductive female system uterus cervix   moderately   male system testis     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

eleven C2H2-type zinc fingers

conjugated

PhosphoP , MetalloP

HOMOLOGY

interspecies	homolog to chimpanzee ZNF711 (99.9 pc)
	homolog to chicken ZNF6 (87.7 pc)

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

acting as a transcriptional activator

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	PHF8 interacts with ZNF711, which binds to a subset of PHF8 target genes, including the XLMR gene KDM5C
	KCTD5 or Cullin3 overexpression increased ZNF711 protein stability

cell & other

REGULATION

Other

phosphorylated upon DNA damage, probably by ATM or ATR

ASSOCIATED DISORDERS

corresponding disease(s)

MRX65

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       XLMR

Susceptibility

Variant & Polymorphism

Candidate gene	for mental retardation
Marker
Therapy target

ANIMAL & CELL MODELS