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FLASH GENE
Symbol ZNF703 contributors: mct - updated : 09-01-2017
HGNC name zinc finger protein 703
HGNC id 25883
Location 8p11.23      Physical location : 37.553.300 - 37.556.396
Synonym name
  • zinc finger elbow-related proline domain protein 1
    • Synonym symbol(s) FLJ14299, ZEPPO1, ZNF503L, ZPO1
    DNA
    TYPE functioning gene
    STRUCTURE 3.09 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2174 - 590 - 2011 21317240
    EXPRESSION
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • regulator of cell adhesion, migration, and proliferation in mammary epithelial cells
  • key regulator of breast cancer progression
  • implicated in the regulation of ESR1 and E2F1 transcription factor
  • prominent role of ZNF703 in transcription modulation, stem cell regulation and luminal B oncogenesis
  • oncogene in Luminal B breast cancer, that differentially regulates luminal and basal progenitors in human mammary epithelium
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CTNND1 (promotes expression of CTNND1 and alters CTNND1 localization upon cell contact with the extracellular matrix)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    preferentially occurs in luminal B breast tumours
    tumoral     --over  
    of ZNF703, ERLIN2, PROSC, GPR124, and BRF2 in urothelial carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS